Analysis Tools
immune system
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• approximately 50% fewer mature CD8+ T cells in the thymus and spleen
• however, overall spleen and thymus cellularities are similar to controls
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• splenocytes have impaired presentation of an OVA epitope that requires cleavage but not of an epitope that does not require cleavage
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• presentation of multiple different types of antigens by dendritic cells in vitro is less able to support proliferation of T cells
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• impaired presentation of lymphochoriomeningitis virus epitopes to T cells in vivo
• however, presentation of MHC class II epitopes (GP61 and NP309) is similar to controls
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• level is about half that of controls
• levels are decreased on CD4+ and CD8+ T cells in the blood, spleen, lymph nodes and thymus, on lymph node B cells, on splenic macrophages, dendritic cells, and B220+ splenocytes
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hematopoietic system
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• approximately 50% fewer mature CD8+ T cells in the thymus and spleen
• however, overall spleen and thymus cellularities are similar to controls
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• splenocytes have impaired presentation of an OVA epitope that requires cleavage but not of an epitope that does not require cleavage
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