All Phenotypes Mir128-2<tm1.1Ans> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mir128-2^tm1.1Ans
targeted mutation 1.1, Anne Schaefer
MGI:5563796

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Camk2a-cre)2Gsc/0	involves: BALB/cJ * C57BL/6J * FVB/N	MGI:5563802
cn2	Gt(ROSA)26Sor^{tm2(CAG-Mir128-2)Ans}/Gt(ROSA)26Sor⁺ Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Camk2a-cre)2Gsc/0	involves: BALB/cJ * C57BL/6J * FVB/N	MGI:5563803
cn3	Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Drd1-cre)EY262Gsat/0	involves: BALB/cJ * C57BL/6J * FVB/N	MGI:5563804
cn4	Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Adora2a-cre)KG139Gsat/0	involves: BALB/cJ * C57BL/6J * FVB/N	MGI:5563805

Allelic Composition	Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Camk2a-cre)2Gsc/0
Genetic Background	involves: BALB/cJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir128-2^tm1.1Ans mutation (0 available); any Mir128-2 mutation (0 available)
Tg(Camk2a-cre)2Gsc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:205260 )

• die at 2 to 3 months of age, similar to germ line null mice

behavior/neurological

hyperactivity ( J:205260 )

• early onset

increased vertical activity ( J:205260 )

seizures ( J:205260 )

nervous system

seizures ( J:205260 )

Allelic Composition	Gt(ROSA)26Sor^{tm2(CAG-Mir128-2)Ans}/Gt(ROSA)26Sor⁺ Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Camk2a-cre)2Gsc/0
Genetic Background	involves: BALB/cJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(CAG-Mir128-2)Ans} mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Mir128-2^tm1.1Ans mutation (0 available); any Mir128-2 mutation (0 available)
Tg(Camk2a-cre)2Gsc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:205260 )

• viable with normal locomotor activity levels

Allelic Composition	Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Drd1-cre)EY262Gsat/0
Genetic Background	involves: BALB/cJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir128-2^tm1.1Ans mutation (0 available); any Mir128-2 mutation (0 available)
Tg(Drd1-cre)EY262Gsat mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:205260 )

• at about 5 months of age

behavior/neurological

hyperactivity ( J:205260 )

• juvenile

• administration of a MAP2K1 specific inhibitor SL327 normalizes locomotor activity

increased vertical activity ( J:205260 )

seizures ( J:205260 )

nervous system

seizures ( J:205260 )

increased dendritic spine number ( J:205260 )

• about a 20% increase in functional dendritic spines in striatal slices

abnormal action potential ( J:205260 )

• enhanced dendritic excitability in striatal slices

Allelic Composition	Mir128-2^tm1.1Ans/Mir128-2^tm1.1Ans Tg(Adora2a-cre)KG139Gsat/0
Genetic Background	involves: BALB/cJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir128-2^tm1.1Ans mutation (0 available); any Mir128-2 mutation (0 available)
Tg(Adora2a-cre)KG139Gsat mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:205260 )

• viable with normal locomotor activity levels

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24