Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir128-2tm1.1Ans mutation
(0 available);
any
Mir128-2 mutation
(0 available)
Tg(Camk2a-cre)2Gsc mutation
(2 available)
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mortality/aging
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• die at 2 to 3 months of age, similar to germ line null mice
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behavior/neurological
nervous system
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(CAG-Mir128-2)Ans mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Mir128-2tm1.1Ans mutation
(0 available);
any
Mir128-2 mutation
(0 available)
Tg(Camk2a-cre)2Gsc mutation
(2 available)
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normal phenotype
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• viable with normal locomotor activity levels
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir128-2tm1.1Ans mutation
(0 available);
any
Mir128-2 mutation
(0 available)
Tg(Drd1-cre)EY262Gsat mutation
(2 available)
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mortality/aging
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• at about 5 months of age
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behavior/neurological
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• juvenile
• administration of a MAP2K1 specific inhibitor SL327 normalizes locomotor activity
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nervous system
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• about a 20% increase in functional dendritic spines in striatal slices
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• enhanced dendritic excitability in striatal slices
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir128-2tm1.1Ans mutation
(0 available);
any
Mir128-2 mutation
(0 available)
Tg(Adora2a-cre)KG139Gsat mutation
(2 available)
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normal phenotype
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• viable with normal locomotor activity levels
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