growth/size/body
• males show a significantly lower total body fat mass than wild-type controls as early as 26 weeks of age
• females exhibit reduced body fat mass at 52 weeks of age, i.e. later than males
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• by one year of age, males are 15% lighter than wild-type males
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• males exhibit a significantly slower growth rate than wild-type controls
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adipose tissue
• males show a significantly lower total body fat mass than wild-type controls as early as 26 weeks of age
• females exhibit reduced body fat mass at 52 weeks of age, i.e. later than males
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skeleton
• less than 20% of mice (1/12 males and 2/10 females) show lordokyphosis at 12 weeks of age, and this frequency increases to ~60% (8/12 males and 6/10 females) by 26 weeks of age, relative to less than 20% (2/10 males and 2/11 females) of age-matched wild-type controls
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