|
Allele Symbol Allele Name Allele ID |
Lncpinttm1Vlcg targeted mutation 1, Velocigene MGI:5563545 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• noticeable at 3 weeks of age
• at 7 weeks of age females and males have a 22% and 29% reduction in body weight compared to sex-matched controls, respectively
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Skin abnormalities and lordokyphosis in Lncpinttm1Vlcg/Lncpinttm1Vlcg mice
 |
• males exhibit a significant reduction in survival relative to heterozygous and wild-type controls over a 1-year observation period
|
|
• mice begin showing signs of early onset aging-like phenotypes at 3 months of age
• however, no signs of tumors or lesions are observed with increasing aging
|
|
• males show a significantly lower total body fat mass than wild-type controls as early as 26 weeks of age
• females exhibit reduced body fat mass at 52 weeks of age, i.e. later than males
|
|
|
• males show significantly decreased lean mass at 52 weeks of age
|
|
• by one year of age, males are more than 30% lighter than wild-type males, whereas females are 27% lighter than wild-type females
|
|
• some mice develop herniation, such as protrusion of the xiphoid process on the chest along with thinning of the abdominal wall
|
|
• although both male and females show a significantly slower growth rate than wild-type controls, this is more pronounced in males
|
|
• mice show variable but age-dependent hindlimb clasping when suspended by the tail, suggesting a progressive decline in muscle strength
|
|
• mice show a severe reduction in the thickness of the subcutaneous fat layer as they age
|
|
• ventral and dorsal skin sections indicate significant fibrosis
|
|
• mice show a severe reduction in the thickness of the subcutaneous fat layer as they age
|
|
• males show a significantly lower total body fat mass than wild-type controls as early as 26 weeks of age
• females exhibit reduced body fat mass at 52 weeks of age, i.e. later than males
|
|
• starting at 26 weeks of age
|
|
• starting at 26 weeks of age
|
|
• both males and females show significantly reduced muscle mass for the gastrocnemius complex and tibialis anterior starting at 26 weeks of age
|
|
• some mice exhibit protrusion of the xiphoid process on the chest along with thinning of the abdominal wall
|
|
• ~70% (6/9 males and 7/10 females) of mice exhibit lordokyphosis at 12 weeks of age, and this frequency increases to ~90% (7/8 males and 8/9 females) by 26 weeks of age
• ~95% of mice (9/9 including those that died before the 52 week time-point, or 6/6 surviving males and 8/9 surviving females) display lordokyphosis by 52 weeks of age; in contrast, less than 20% (2/10 males and 2/11 females) of wild-type controls show mild lordokyphosis at 26 weeks of age, and this frequency does not increase with age
|
|
• mice show significantly lower femur bone mineral density than wild-type controls as they age
|
|
• starting at 26 weeks of age
|
|
• starting at 26 weeks of age
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• males show a significantly lower total body fat mass than wild-type controls as early as 26 weeks of age
• females exhibit reduced body fat mass at 52 weeks of age, i.e. later than males
|
|
|
• by one year of age, males are 15% lighter than wild-type males
|
|
|
• males exhibit a significantly slower growth rate than wild-type controls
|
|
• males show a significantly lower total body fat mass than wild-type controls as early as 26 weeks of age
• females exhibit reduced body fat mass at 52 weeks of age, i.e. later than males
|
|
• less than 20% of mice (1/12 males and 2/10 females) show lordokyphosis at 12 weeks of age, and this frequency increases to ~60% (8/12 males and 6/10 females) by 26 weeks of age, relative to less than 20% (2/10 males and 2/11 females) of age-matched wild-type controls
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/07/2024 MGI 6.23 |
|
|
|
||
Analysis Tools