Phenotypes associated with this allele

• Allele Symbol: Pds5b^tm1.2Alos
• Allele Name: targeted mutation 1.2, Ana Losada
• Allele ID: MGI:5563482
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pds5b^tm1.2Alos/Pds5b^tm1.2Alos	involves: 129S2/SvPas	MGI:5563520

Genotype
MGI:5563520

hm1

• Allelic Composition: Pds5b^tm1.2Alos/Pds5b^tm1.2Alos
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:205601 )

• fewer than expected mice are present between E16.5 and E18.5

cellular

abnormal cell nucleus morphology ( J:205601 )

binucleate ( J:205601 )

• in mouse embryonic fibroblasts

abnormal chromosome morphology ( J:205601 )

• defective centromeric cohesion in mouse embryonic fibroblasts

aneuploidy ( J:205601 )

• in mouse embryonic fibroblasts and fetal hepatocytes

increased micronucleus incidence ( J:205601 )

• in mouse embryonic fibroblasts

abnormal mitosis ( J:205601 )

• defective mitotic progression in mouse embryonic fibroblasts (MEFs) with impaired chromosome segregation

• aberrant anaphase in MEFs with lagging chromosomes or chromatin bridges

decreased cell proliferation ( J:205601 )

• in mouse embryonic fibroblasts

adipose tissue

decreased brown adipose tissue amount ( J:205601 )

• thinner