Phenotypes associated with this allele

• Allele Symbol: Ikzf1^tm1.1Smale
• Allele Name: targeted mutation 1.1, Stephen T Smale
• Allele ID: MGI:5563075
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ikzf1^tm1.1Smale/Ikzf1^tm1.1Smale	B6.Cg-Ikzf1^tm1.1Smale	MGI:5563079
ht2	Ikzf1^tm1.1Smale/Ikzf1^tm2Kge	involves: 129S4/SvJae * C57BL/6	MGI:5563081

Genotype
MGI:5563079

hm1

• Allelic Composition: Ikzf1^tm1.1Smale/Ikzf1^tm1.1Smale
• Genetic Background: B6.Cg-Ikzf1^tm1.1Smale

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:208211 )

N • unlike Ikzf1^tm2Kge homozygotes, mice exhibit normal numbers of pre-pro-B cells

N • mice exhibit normal numbers of pro-B, pre-BI cells, double-negative T cells, DN2, DN3 cells, double-positive thymocytes and single-positive thymocytes

N • normal numbers of fetal T cells

thymus hypoplasia ( J:208211 )

• slight

decreased DN1 thymic pro-T cell number ( J:208211 )

decreased B cell number ( J:208211 )

• smaller number of conventional B cells in the bone marrow and spleen of adult mice

• in the adult thymus

• moderately reduced in the fetus

decreased immature B cell number ( J:208211 )

• to a greater extent than in Ikzf1^tm2.1Smale

decreased mature B cell number ( J:208211 )

• recirculating; to a greater extent than in Ikzf1^tm2.1Smale

decreased B-1a cell number ( J:208211 )

• in the peritoneal cavity

decreased B-1b cell number ( J:208211 )

• in the peritoneal cavity

decreased pre-B cell number ( J:208211 )

• of large and small pre-BII cells

neoplasm

neoplasm ( J:208211 )

N • mice do not develop lymphomas

hematopoietic system

thymus hypoplasia ( J:208211 )

• slight

decreased DN1 thymic pro-T cell number ( J:208211 )

decreased B cell number ( J:208211 )

• smaller number of conventional B cells in the bone marrow and spleen of adult mice

• in the adult thymus

• moderately reduced in the fetus

decreased immature B cell number ( J:208211 )

• to a greater extent than in Ikzf1^tm2.1Smale

decreased mature B cell number ( J:208211 )

• recirculating; to a greater extent than in Ikzf1^tm2.1Smale

decreased B-1a cell number ( J:208211 )

• in the peritoneal cavity

decreased B-1b cell number ( J:208211 )

• in the peritoneal cavity

decreased pre-B cell number ( J:208211 )

• of large and small pre-BII cells

endocrine/exocrine glands

thymus hypoplasia ( J:208211 )

• slight

decreased DN1 thymic pro-T cell number ( J:208211 )

Genotype
MGI:5563081

ht2

• Allelic Composition: Ikzf1^tm1.1Smale/Ikzf1^tm2Kge
• Genetic Background: involves: 129S4/SvJae * C57BL/6

mortality/aging

lethality, complete penetrance ( J:208211 )

• no mice are produced presumably because of embryonic lethality of Ikzf1^tm2Kge on a C57BL/6 background