Phenotypes associated with this allele

• Allele Symbol: Jak2^m1Dlbr
• Allele Name: mutation 1, Dwayne L Barber
• Allele ID: MGI:5562422
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jak2^m1Dlbr/Jak2^m1Dlbr	involves: 129S1/SvImJ * C57BL/6J	MGI:5562426
ht2	Jak2^m1Dlbr/Jak2^+	involves: 129S1/SvImJ * C57BL/6J	MGI:5562425
ht3	Jak2^m1Dlbr/Jak2^tm1Jni	involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J	MGI:5562428

Genotype
MGI:5562426

hm1

• Allelic Composition: Jak2^m1Dlbr/Jak2^m1Dlbr
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:207740 )

• no viable mice are present after E14.5

hematopoietic system

anemia ( J:207740 )

• at E12.5

Genotype
MGI:5562425

ht2

• Allelic Composition: Jak2^m1Dlbr/Jak2⁺
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J

hematopoietic system

hematopoietic system phenotype ( J:207740 )

N • bone marrow exhibits normal CFU-megakaryocyte assays

N • mice exhibit normal response to 5-fluorouracil and phenylhydrazine challenge

increased megakaryocyte cell number ( J:207740 )

• in the bone marrow

decreased erythrocyte cell number ( J:207740 )

♀ • in female, but not male, mice at 8 weeks

thrombocytosis ( J:207740 )

• thrombocythemia in male and female mice at 8 weeks

Genotype
MGI:5562428

ht3

• Allelic Composition: Jak2^m1Dlbr/Jak2^tm1Jni
• Genetic Background: involves: 129P2/OlaHsd * 129S1/SvImJ * C57BL/6J

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:207740 )

• no viable mice are present after E14.5

hematopoietic system

anemia ( J:207740 )

• at E12.5 and E14.5