All Phenotypes Dclre1c<m1Brck> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Dclre1c^m1Brck/Dclre1c^m1Brck
Genetic Background	involves: C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclre1c^m1Brck mutation (1 available); any Dclre1c mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

absent B cells ( J:207533 )

absent T cells ( J:207533 )

immune system

absent B cells ( J:207533 )

absent T cells ( J:207533 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:207533 )

N	• mice exhibit normal numbers of CD11c+MHCII+ dendritic cells, CD3-NK1.1+ NK cells, CD11b+ monocytes and Gr1+ granulocytes

decreased DN4 thymocyte number ( J:207533 )

• absent

• hardly any double positive thymocytes

absent B cells ( J:207533 )

decreased pre-B cell number ( J:207533 )

• virtually absent

hematopoietic system

decreased DN4 thymocyte number ( J:207533 )

• absent

• hardly any double positive thymocytes

absent B cells ( J:207533 )

decreased pre-B cell number ( J:207533 )

• virtually absent

endocrine/exocrine glands

decreased DN4 thymocyte number ( J:207533 )

• absent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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