All Phenotypes Kmt2a<tm2.1Mlc> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kmt2a^tm2.1Mlc
targeted mutation 2.1, Michael L Cleary
MGI:5561120

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kmt2a^tm2.1Mlc/Kmt2a^tm2.1Mlc	involves: 129P2/OlaHsd * C57BL/6	MGI:5561126

Allelic Composition	Kmt2a^tm2.1Mlc/Kmt2a^tm2.1Mlc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2a^tm2.1Mlc mutation (0 available); any Kmt2a mutation (135 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• mice die mid-gestation

hematopoietic system

• fetal liver cells transplanted into lethally irradiated mice fail to reconstitute the hematopoietic system unlike wild-type cells

• reduced LKS compartment, which includes hematopoietic stem cells and multi-potent progenitors, in the fetal liver

cardiovascular system

hemorrhage ( J:207555 )

homeostasis/metabolism

skin edema ( J:207555 )

integument

skin edema ( J:207555 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23