Phenotypes associated with this allele

• Allele Symbol: Tg(Ins1-cre)25Utr
• Allele Name: transgene insertion 25, Ken-ichi Yagami
• Allele ID: MGI:5560759
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ddit4l^em2Omunc/Ddit4l^em2Omunc Tg(Ins1-cre)25Utr/0	involves: C57BL/6J * C57BL/6N	MGI:8226104

Genotype
MGI:8226104

cn1

• Allelic Composition: Ddit4l^em2Omunc/Ddit4l^em2Omunc; Tg(Ins1-cre)25Utr/0
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

improved glucose tolerance ( J:370104 )

• in the streptozotocin (STZ)-induced diabetic model, both male and female STZ-treated mice show improved glucose tolerance in an IPGTT test with a significantly decreased area under the curve (AUC) relative to STZ-treated controls

• in the high-fat diet (HFD)-induced diabetic model, 8- and 12-week-old HFD-fed males show improved glucose tolerance in an IPGTT test with a significantly decreased AUC relative to HFD-fed control males

• however, insulin sensitivity remains normal in both sexes after STZ treatment and is also unaffected in males after HFD feeding

growth/size/body

growth/size/body region phenotype ( J:370104 )

♂N • male mice fed a HFD show no significant changes in body weight gain relative to HFD-fed control males