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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Agxt2tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:5560668
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Agxt2tm1Lex/Agxt2tm1Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:5562686


Genotype
MGI:5562686
hm1
Allelic
Composition		 Agxt2tm1Lex/Agxt2tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agxt2tm1Lex mutation (1 available); any Agxt2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
hypertension ( J:207876 )
• in male mice under terminal anesthesia
increased vasodilation ( J:207876 )
• increased maximal response following acetylcholine treatment

homeostasis/metabolism
increased circulating citrulline level ( J:207876 )
• small but statistically significant increase in circulating L-citrulline
• however, circulating levels of L-alanine, L-arginine, or L-glutamine are normal

renal/urinary system
renal/urinary system phenotype ( J:207876 )
N
• kidney development is normal

muscle
increased vasodilation ( J:207876 )
• increased maximal response following acetylcholine treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory