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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdk5r1tm2.1Lht
targeted mutation 2.1, Li-Huei Tsai
MGI:5560495
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cdk5r1tm2.1Lht/Cdk5r1tm2.1Lht B6.129-Cdk5r1tm2.1Lht MGI:5560898
cx2
 		Cdk5r1tm2.1Lht/?
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/? 		involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:5560900


Genotype
MGI:5560898
hm1
Allelic
Composition		 Cdk5r1tm2.1Lht/Cdk5r1tm2.1Lht
Genetic
Background		 B6.129-Cdk5r1tm2.1Lht
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5r1tm2.1Lht mutation (1 available); any Cdk5r1 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
slow extinction of fear memory ( J:208030 )
• impaired memory extinction
• 8 week old males exhibit higher levels of freezing behavior in context dependent memory test
• in repeated probe trials, males show increased crossing of platform location in Morris water maze and continued to explore the target quadrant as compared to wild type

nervous system
abnormal excitatory postsynaptic potential ( J:208030 )
• field excitatory postsynaptic potential (fEPSP) was not reduced following Abeta1-42 induced synaptic depression in hippocampal slices relative to controls
abnormal long-term depression ( J:208030 )
• NMDAR-dependent long term depression using single pulse low frequency stimulation was increased over baseline relative to controls




Genotype
MGI:5560900
cx2
Allelic
Composition		 Cdk5r1tm2.1Lht/?
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk5r1tm2.1Lht mutation (1 available); any Cdk5r1 mutation (13 available)
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:208030 )
N
• long term depression is restored to wild type levels as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
• anxiety, cognitive performance and contextual/cued fear conditioning are restored to wild type levels as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas

nervous system
nervous system phenotype ( J:208030 )
N
• presence of reactive astrocytes and activated microglia is close to wild type levels as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
amyloid beta deposits ( J:208030 )
• plaque load in the hippocampus is reduced as compared to mice with Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone, but still higher than wild type
• 20-30% reduction of levels of Abeta42 and Abeta40 in the hippocampus as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas

homeostasis/metabolism
amyloid beta deposits ( J:208030 )
• plaque load in the hippocampus is reduced as compared to mice with Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas alone, but still higher than wild type
• 20-30% reduction of levels of Abeta42 and Abeta40 in the hippocampus as compared to mice carrying only Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory