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Allele Symbol Allele Name Allele ID |
Tg(Vil1-Lin28b,-tdTomato)MedAru transgene insertion Med, Anil K Rustgi MGI:5560201 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• apparent rescue of Paneth cell phenotype in cells expressing both transgenes
• rescue of crypt hyperplasia in mice expressing both transgenes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mucosal hypertrophy
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• increase in small intestinal mass but no increase in length
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• crypt proliferation frequently extends downward toward the bottom of the crypts
• increase in apoptosis coincident with the increase in proliferation
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• decrease in the number of Paneth cells
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• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age
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• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age
• lesions are typically polyp-shaped or flat
• adenomas and adenocarcinomas are seen in the small intestine only
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• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age
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• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age
• lesions are typically polyp-shaped or flat
• adenomas and adenocarcinomas are seen in the small intestine only
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• crypt proliferation frequently extends downward toward the bottom of the crypts
• increase in apoptosis coincident with the increase in proliferation
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• decrease in the number of Paneth cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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