Phenotypes associated with this allele

• Allele Symbol: Calca^{tm1.1(cre/EGFP)Rpa}
• Allele Name: targeted mutation 1.1, Richard D Palmiter
• Allele ID: MGI:5559692
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Calca^tm1.1(cre/EGFP)Rpa/Calca^+	involves: 129S6/SvEvTac * C57BL/6NCrl	MGI:5559750

Genotype
MGI:5559750

ht1

• Allelic Composition: Calca^{tm1.1(cre/EGFP)Rpa}/Calca⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased food intake ( J:206070 )

• when neurons of the outer external lateral subdivision of the PBN (PBelo) are transduced with a cre-dependent channelrhodopsin-mCherry vector, photostimulation of projections to the central nucleus of the amygdala (CeAlc) reversibly suppressed food intake in animals whereas stimulation of PBelo projections to the bed nucleus of the stria terminalis (BNST) does not alter food intake significantly

nervous system

abnormal excitatory postsynaptic currents ( J:206070 )

• in mice injected with a cre-dependent channelrhodopsin (ChR2)-mCherry vector, optical stimulation of transduced fibers in the central nucleus of the amygdala (CeAlc) induces excitatory postsynaptic currents as well as increased firing rates in these neurons in acute brain slices