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Allele Symbol Allele Name Allele ID |
Tg(KRT14-HPV8)85Vuc transgene insertion 85, Herbert Pfister MGI:5559369 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: mice show a lower penetrance of papilloma development on the C57BL/6 background than on the FVB/N background
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• Background Sensitivity: mice show a lower penetrance of papilloma development on the C57BL/6 background than on the FVB/N background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• develop severe hyperkeratosis leading to cutaneous horns
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• Background Sensitivity: mice show a higher penetrance of papilloma development on the FVB/N background than on the C57BL/6 background; papillomas present with mild or moderate dysplasia
• develop lesions on the laterodorsal trunk at 28 weeks of age
• males develop tumors earlier than females
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• 2 of 85 mice that develop papilloma show invasive squamous cell carcinoma
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• Background Sensitivity: mice show a higher penetrance of papilloma development on the FVB/N background than on the C57BL/6 background; papillomas present with mild or moderate dysplasia
• develop lesions on the laterodorsal trunk at 28 weeks of age
• males develop tumors earlier than females
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• 2 of 85 mice that develop papilloma show invasive squamous cell carcinoma
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| skin cancer | DOID:4159 | J:96784 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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