All Phenotypes Slx4<tm1.2Jrou> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slx4^tm1.2Jrou
targeted mutation 1.2, John Rouse
MGI:5559219

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slx4^tm1.2Jrou/Slx4^tm1.2Jrou	B6.129P2-Slx4^tm1.2Jrou	MGI:5559492
hm2	Slx4^tm1.2Jrou/Slx4^tm1.2Jrou	involves: 129P2/OlaHsd * C57BL/6	MGI:5559490
cx3	Fan1^tm1.1Jrou/Fan1^tm1.1Jrou Slx4^tm1.2Jrou/Slx4^tm1.2Jrou	involves: 129P2/OlaHsd	MGI:5897800

Allelic Composition	Slx4^tm1.2Jrou/Slx4^tm1.2Jrou
Genetic Background	B6.129P2-Slx4^tm1.2Jrou

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slx4^tm1.2Jrou mutation (0 available); any Slx4 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:204996 )

• fewer than expected mice are obtained at E13.5

preweaning lethality, incomplete penetrance ( J:204996 )

• fewer than expected mice are obtained at weaning

reproductive system

small testis ( J:204996 )

• at 10 weeks

cellular

increased sensitivity to induced cell death ( J:204996 )

• in mouse embryonic fibroblasts treated with DNA interstrand crosslinking agents (nitrogen mustard and MMC)

abnormal DNA repair ( J:204996 )

induced chromosome breakage ( J:204996 )

• chromatid breaks and radial structures in MMC-treated mouse embryonic fibroblasts

endocrine/exocrine glands

small testis ( J:204996 )

• at 10 weeks

homeostasis/metabolism

abnormal DNA repair ( J:204996 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Fanconi anemia complementation group P	DOID:0111092	OMIM:613951	J:204996
Fanconi-like syndrome		DOID:0090066	OMIM:227850	J:204996

Allelic Composition	Slx4^tm1.2Jrou/Slx4^tm1.2Jrou
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slx4^tm1.2Jrou mutation (0 available); any Slx4 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:204996 )

• no mice are obtained from crossing heterozygotes

Allelic Composition	Fan1^tm1.1Jrou/Fan1^tm1.1Jrou Slx4^tm1.2Jrou/Slx4^tm1.2Jrou
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fan1^tm1.1Jrou mutation (0 available); any Fan1 mutation (98 available)
Slx4^tm1.2Jrou mutation (0 available); any Slx4 mutation (57 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:232403 )

• increase in sensitivity to mitomycin C compared to either single homozygote

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23