Phenotypes associated with this allele

• Allele Symbol: Grm3^tm1Vbn
• Allele Name: targeted mutation 1, Valeria Bruno
• Allele ID: MGI:5558949
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grm3^tm1Vbn/Grm3^tm1Vbn	B6.129P2-Grm3^tm1Vbn	MGI:5559018

Genotype
MGI:5559018

hm1

• Allelic Composition: Grm3^tm1Vbn/Grm3^tm1Vbn
• Genetic Background: B6.129P2-Grm3^tm1Vbn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal astrocyte physiology ( J:202321 )

• in coculture experiments, the neuroprotection of LY379268 treatment is lost when wild-type or deficient neurons are plated over deficient astrocytes

• in coculture experiments, the neuroprotection of LY379268 or MPEP treatment is reduced when neurons from Grm2^tm1Nak homozygotes are plated over deficient astrocytes

• astrocytes cocultured with wild-type neurons results in enhanced NMDA neurotoxicity compared with when wild-type astrocytes are cocultured with wild-type neurons

• however, the neuroprotection of MPEP is normal when wild-type neurons are plated over deficient astrocytes

abnormal neuron physiology ( J:202321 )

• reduced neuroprotection by LY379268 in neurons treated with NMDA

• LY379268-treatment fails to reduce glutamate release unlike in wild-type neurons

• however, GABA release is normally affected by LY379268-treatment