Phenotypes associated with this allele

• Allele Symbol: Mavs^tm1Tsse
• Allele Name: targeted mutation 1, Tsukasa Seya
• Allele ID: MGI:5558893
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mavs^tm1Tsse/Mavs^tm1Tsse Tg(PVR)1Kkst/0	involves: 129 * C57BL/6 * ICR	MGI:5558902
cx2	Ddx60^tm1b(EUCOMM)Wtsi/Ddx60^tm1b(EUCOMM)Wtsi Mavs^tm1Tsse/Mavs^tm1Tsse	involves: 129 * C57BL/6N	MGI:5903064

Genotype
MGI:5558902

cx1

• Allelic Composition: Mavs^tm1Tsse/Mavs^tm1Tsse; Tg(PVR)1Kkst/0
• Genetic Background: involves: 129 * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:179625 )

• when poliovirus loads is not very high, polivirus-infected mice exhibit lightly less lethality compared with Tg(PVR)1Kkst mice

• however, poliovirus-infected mice exhibit normal lethality at higher levels

immune system

abnormal interferon-alpha secretion ( J:179625 )

• following injection of high poliovirus titers, mice exhibit less of an increase in serum IFN Tg(PVR)1Kkst mice

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:179625 )

• when poliovirus loads is not very high, polivirus-infected mice exhibit lightly less lethality compared with Tg(PVR)1Kkst mice

• however, poliovirus-infected mice exhibit normal lethality at higher levels

Genotype
MGI:5903064

cx2

• Allelic Composition: Ddx60^{tm1b(EUCOMM)Wtsi}/Ddx60^{tm1b(EUCOMM)Wtsi}; Mavs^tm1Tsse/Mavs^tm1Tsse
• Genetic Background: involves: 129 * C57BL/6N
• Cell Lines: EPD0327_7_A05

mortality/aging

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:228452 )

• more so than in Ddx60^{tm1b(EUCOMM)Wtsi} homozygotes after VSV infection

immune system

increased susceptibility to Riboviria infection induced morbidity/mortality ( J:228452 )

• more so than in Ddx60^{tm1b(EUCOMM)Wtsi} homozygotes after VSV infection