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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il5tm1.1(icre)Lky
targeted mutation 1.1, Richard M Locksley
MGI:5558083
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Il5tm1.1(icre)Lky/Il5+ C57BL/6-Il5tm1.1(icre)Lky MGI:5558888
cn2
 		Gt(ROSA)26Sortm1(DTA)Lky/?
Il5tm1.1(icre)Lky/Il5+
Rag1tm1Mom/Rag1tm1Mom 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:5558890


Genotype
MGI:5558888
ht1
Allelic
Composition		 Il5tm1.1(icre)Lky/Il5+
Genetic
Background		 C57BL/6-Il5tm1.1(icre)Lky
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il5tm1.1(icre)Lky mutation (1 available); any Il5 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating interleukin-5 level ( J:206097 )
• serum has about half of the normal level of Il5

immune system
decreased circulating interleukin-5 level ( J:206097 )
• serum has about half of the normal level of Il5




Genotype
MGI:5558890
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Lky/?
Il5tm1.1(icre)Lky/Il5+
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Lky mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
Il5tm1.1(icre)Lky mutation (1 available); any Il5 mutation (32 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:206097 )
• no increase in type 2 innate lymphoid cells (ILC2) or induction of eotaxin-1 (Ccl11) is detected in lungs in response to administration of Il2 and Il33 in contrast to control mice lacking DTA expression which have a higher ILC2 population and Ccl11 expression




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory