All Phenotypes Ifngr1<tm1.1Rds> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ifngr1^tm1.1Rds
targeted mutation 1.1, Robert D Schreiber
MGI:5558045

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ifngr1^tm1.1Rds/Ifngr1^tm1.1Rds Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	B6NTac.Cg-Ifngr1^tm1.1Rds Commd10^{Tg(Vav1-icre)A2Kio}	MGI:5558063
cn2	Ifngr1^tm1.1Rds/Ifngr1^tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach/0	B6NTac.Cg-Ifngr1^tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach	MGI:5558060

Allelic Composition	Ifngr1^tm1.1Rds/Ifngr1^tm1.1Rds Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	B6NTac.Cg-Ifngr1^tm1.1Rds Commd10^{Tg(Vav1-icre)A2Kio}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Ifngr1^tm1.1Rds mutation (1 available); any Ifngr1 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:206257 )

• in mice infected with L. monocytogenes

immune system

increased susceptibility to bacterial infection ( J:206257 )

• mice infected with L. monocytogenes exhibit increased mortality and spleen and liver bacterial counts compared with control mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:206257 )

• in mice infected with L. monocytogenes

Allelic Composition	Ifngr1^tm1.1Rds/Ifngr1^tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach/0
Genetic Background	B6NTac.Cg-Ifngr1^tm1.1Rds Tg(Itgax-cre,-EGFP)4097Ach

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngr1^tm1.1Rds mutation (1 available); any Ifngr1 mutation (52 available)
Tg(Itgax-cre,-EGFP)4097Ach mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:206257 )

• in mice infected with L. monocytogenes

immune system

decreased interferon-gamma secretion ( J:206257 )

• from NK and NK T cells of mice infected with L. monocytogenes

• however, production in CD8+ T cells is normal

decreased interleukin-12b secretion ( J:206257 )

• reduced from CD8a+ dendritic cells of mice infected with L. monocytogenes

• production from Ly6c+ monocytes is temporarily delayed

increased susceptibility to bacterial infection ( J:206257 )

• mice infected with L. monocytogenes exhibit increased mortality, spleen and liver bacterial counts, reduced IL12b production from CD8a+ dendritic cells compared with control mice

• intravenous L. monocytogenes infection results in reduced bacterial burden

• however, treatment with IL4 neutralizing antibody reduces bacterial burden

increased susceptibility to bacterial infection induced morbidity/mortality ( J:206257 )

• in mice infected with L. monocytogenes

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