Phenotypes associated with this allele

• Allele Symbol: Scn11a^tm1.1Ikth
• Allele Name: targeted mutation 1.1, Ingo Kurth
• Allele ID: MGI:5558025
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Scn11a^tm1.1Ikth/Scn11a^+	involves: 129 * BALB/c * C57BL/6	MGI:5558028
ht2	Scn11a^tm1Mdba/Scn11a^tm1.1Ikth	involves: 129 * BALB/c * C57BL/6	MGI:5558031

Genotype
MGI:5558028

ht1

• Allelic Composition: Scn11a^tm1.1Ikth/Scn11a⁺
• Genetic Background: involves: 129 * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:206848 )

• dorsal ganglion neurons exhibit a shifted resting membrane potential indicating active channels under resting conditions compared with wild-type cell

• diminished peak current densities at depolarized voltage

• greater inward current under resting conditions

abnormal action potential ( J:206848 )

• reduced in dorsal ganglion neurons

abnormal afterhyperpolarization ( J:206848 )

• less pronounced in dorsal ganglion neurons

abnormal miniature excitatory postsynaptic currents ( J:206848 )

• less frequent

abnormal channel response ( J:206848 )

• intermediately diminished peak current densities at depolarized voltage

integument

integument phenotype ( J:206848 )

N • prior to induction of inflammation, mice exhibit normal withdrawal threshold for plantar mechanical and thermal stimulation

skin lesions ( J:206848 )

• severe, self-inflicted tissue lesions in some mice

behavior/neurological

abnormal nociception after inflammation ( J:206848 )

• after zymogen-induced inflammation, mice exhibit a smaller reduction in the withdrawal threshold, indicating less thermal and mechanical hyperalgesia, and less protective behavior compared with wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary sensory neuropathy		DOID:0050548	OMIM:PS162400	J:206848

Genotype
MGI:5558031

ht2

• Allelic Composition: Scn11a^tm1Mdba/Scn11a^tm1.1Ikth
• Genetic Background: involves: 129 * BALB/c * C57BL/6

nervous system

abnormal nervous system electrophysiology ( J:206848 )

• diminished peak current densities at depolarized voltage

abnormal channel response ( J:206848 )

• channel inactivation is more pronounced than in wild-type cells