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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mastltm1.1Mama
targeted mutation 1.1, Marcos Malumbres
MGI:5556126
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mastltm1.1Mama/Mastltm1.1Mama Not Specified MGI:5556129
cn2
 		Mastltm1.1Mama/Mastltm1.1Mama
Polr2atm1(cre/ERT2)Bbd/Polr2a+ 		Not Specified MGI:5556128


Genotype
MGI:5556129
cn1
Allelic
Composition		 Mastltm1.1Mama/Mastltm1.1Mama
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mastltm1.1Mama mutation (0 available); any Mastl mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitosis ( J:201971 )
• mitotic aberrations in prometaphase, including defective chromosome condensation and abnormal spindles in primary MEFs following acute expression of cre
• about 75% of MEFs display mitotic arrest following acute expression of cre
• duration of mitosis is increased in primary MEFs following acute expression of cre
• however, no differences in the kinetics of mitotic entry are detected and the function of the spindle assembly checkpoint appears normal in primary MEFs following acute expression of cre
decreased fibroblast proliferation ( J:201971 )
• in primary MEFs following acute expression of cre




Genotype
MGI:5556128
cn2
Allelic
Composition		 Mastltm1.1Mama/Mastltm1.1Mama
Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mastltm1.1Mama mutation (0 available); any Mastl mutation (36 available)
Polr2atm1(cre/ERT2)Bbd mutation (3 available); any Polr2a mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitosis ( J:201971 )
• following treatment with tamoxifen at E12.5, at E14.5 an increase in mitotic figures is seen in the neuroepithelium
• mitotic figures display an accumulation of prometaphases/metaphases

embryo
abnormal embryonic neuroepithelium morphology ( J:201971 )
• following treatment with tamoxifen at E12.5, at E14.5 an increase in mitotic figures is seen in the neuroepithelium

nervous system
abnormal embryonic neuroepithelium morphology ( J:201971 )
• following treatment with tamoxifen at E12.5, at E14.5 an increase in mitotic figures is seen in the neuroepithelium




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory