Phenotypes associated with this allele

• Allele Symbol: Tg(DUX4*)1Maar
• Allele Name: transgene insertion 1, Silvere van der Maarel
• Allele ID: MGI:5555034
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(DUX4*)1Maar/?	involves: C57BL/6J * CBA/J	MGI:5555035

Genotype
MGI:5555035

tg1

• Allelic Composition: Tg(DUX4*)1Maar/?
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased incidence of corneal inflammation ( J:195481 )

• mice develop progressive keratitis of unknown etiology

muscle

delayed skeletal muscle regeneration ( J:195481 )

• after induction of severe muscle damage by cardiotoxin injection, mice show a small delay in muscle regeneration

• however, overall morphology and histology of limb and some head muscles appears normal, grip strength is normal, and inducing mild muscle damage by down-hill running does not result in muscle weakness or damage

vision/eye

increased incidence of corneal inflammation ( J:195481 )

• mice develop progressive keratitis of unknown etiology

abnormal eye morphology ( J:195481 )

• 54% of mice develop eye abnormalities at round 8-12 weeks of age