All Phenotypes Actr8<tm1.1(KOMP)Vlcg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Actr8^{tm1.1(KOMP)Vlcg}/Actr8^{tm1.1(KOMP)Vlcg}	B6N(Cg)-Actr8^{tm1.1(KOMP)Vlcg}/J	MGI:5756648
ht2	Actr8^{tm1.1(KOMP)Vlcg}/Actr8⁺	B6N(Cg)-Actr8^{tm1.1(KOMP)Vlcg}/J	MGI:5756647

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

failure to gastrulate ( J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 , J:279207 )

IMPC - JAX (J:211773)

MGI

• homozygous embryos are recovered at lower than expected Mendelian ratios at E7.5 (11% versus 25%) and arrest prior to gastrulation (J:279207)

embryonic lethality, complete penetrance ( J:279207 )

• no homozygous embryos are recovered at E9.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Allelic Composition	Actr8^{tm1.1(KOMP)Vlcg}/Actr8⁺
Genetic Background	B6N(Cg)-Actr8^{tm1.1(KOMP)Vlcg}/J
Cell Lines	19162A-A6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actr8^{tm1.1(KOMP)Vlcg} mutation (1 available); any Actr8 mutation (32 available)

Data Sources

IMPC Data for Actr8

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:211773 )

IMPC - JAX

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

IMPC - JAX

decreased hematocrit ( J:211773 )

IMPC - JAX

decreased hemoglobin content ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased circulating sodium level ( J:211773 )

IMPC - JAX

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23