Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprk1tm1.1Waca mutation
(0 available);
any
Oprk1 mutation
(29 available)
Tg(Slc6a3-icre)9075Gsc mutation
(0 available)
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behavior/neurological
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• mice exhibit a normal response to agonist U50,488-induced analgesia relative to control mice, as shown by similarly increased tail withdrawal latencies in the warm water tail-flick assay
• baseline tail withdrawal latencies are not significantly altered in the tail-flick assay
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• mice exhibit significantly greater locomotor sensitization to cocaine (15 mg/kg) than control mice at day 8 of testing
• however, no differences are detected in a cocaine conditioned place preference paradigm following conditioning with 5 mg/kg or 1.25 mg/kg cocaine
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• mice spend significantly more time than control mice in the center of the open field during the final 45 min of the test session, indicating an anxiolytic-like effect
• mice show significantly shorter latencies to first enter the light side of the light/dark box, with no differences in total time spent in the light compartment relative to control mice
• however, no differences are detected in open arm time or open arm entries in the elevated plus maze test
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1Rsp mutation
(1 available);
any
Grin1 mutation
(64 available)
Tg(Slc6a3-icre)9075Gsc mutation
(0 available)
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nervous system
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• cocaine-induced synaptic strengthening in the ventral tegmental area does not occur in mice after cre activity is induced
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• NMDA-mediated excitatory postsynaptic currents are completely abolished in the ventral tegmental area of mice after cre activity is induced
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behavior/neurological
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• mice that have had cre activity induced and were conditioned to associate a certain cage environment with cocaine do not reinstate their cocaine-seeking behavior when administered the drug after a 16 day extinction phase
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria1tm2Rsp mutation
(1 available);
any
Gria1 mutation
(62 available)
Tg(Slc6a3-icre)9075Gsc mutation
(0 available)
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behavior/neurological
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• mice do not lose the preference for an environment where cocaine was previously administered (i.e. conditioned place preference) even after 16 days have passed since the last cocaine dosing
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nervous system
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• there is no increase in the ratio of AMPA-/NMDA- mediated receptor currents for the ventral tegmental area isolated from mice treated with cocaine as occurs in wild-type controls
• cocaine-induced synaptic strengthening in the ventral tegmental area does not occur in these mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1Rsp mutation
(1 available);
any
Grin1 mutation
(64 available)
Tg(Slc6a3-icre)9075Gsc mutation
(0 available)
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behavior/neurological
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• mice that were previously conditioned to associate a certain cage environment with cocaine do not reinstate their cocaine-seeking behavior when administered the drug after a 16 day extinction phase
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nervous system
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• basal glutamate-mediated receptor currents are enhanced in these mice
• cocaine-induced synaptic strengthening in the ventral tegmental area does not occur in these mice
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• a higher occurrence of spontaneous AMPA excitatory postsynaptic currents occurs in the ventral tegmental area
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• NMDA-mediated excitatory postsynaptic currents are completely abolished in the ventral tegmental area of these mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria2tm3Rsp mutation
(1 available);
any
Gria2 mutation
(75 available)
Tg(Slc6a3-icre)9075Gsc mutation
(0 available)
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nervous system
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• the ratio of AMPA/NMDA-mediated receptor currents in the ventral tegmental area is significantly reduced compared to controls
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Analysis Tools