All Phenotypes Igh<tm1.1Vmd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igh^tm1.1Vmd
targeted mutation 1.1, Vishva M Dixit
MGI:5553164

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm1.1Vmd/Igh^tm1.1Vmd	involves: C57BL/6	MGI:5553165
ht2	Igh^tm1.1Vmd/Igh⁺	involves: C57BL/6	MGI:5553166

Allelic Composition	Igh^tm1.1Vmd/Igh^tm1.1Vmd
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1.1Vmd mutation (0 available); any Igh mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:201147 )

N	• splenocyte cultures stimulated with LPS alone or LPS and IL4 produce normal numbers of IgM+ cells • mice exhibit normal somatic hypermutation

abnormal class switch recombination ( J:201147 )

• 10-fold reduction in class switch recombination in IgG1+ clones and 7-fold increase in IgE+ clones after LPS and IL4 stimulation

• class switch recombination is largely direct instead of sequential

• endogenous Switch mu intraswitch recombination is reduced compared to in wild-type mice

increased IgE level ( J:201147 )

• 6-fold increase in IgE+ B cells in splenocyte cultures stimulated with LPS and IL4

• 4-fold increase in IgE+ cells in splenocyte cultures stimulated with LPS alone

• in unchallenged mice

• in mice in response to a variety of systemic and local challenges (TNP-OVA and infection with Nippostrongylus brasiliensis)

decreased IgG1 level ( J:201147 )

• 11-fold decrease in IgG1+ B cells in splenocyte cultures stimulated with LPS and IL4

decreased IgG3 level ( J:201147 )

• from splenocytes stimulated with LPS alone

hematopoietic system

abnormal class switch recombination ( J:201147 )

• 10-fold reduction in class switch recombination in IgG1+ clones and 7-fold increase in IgE+ clones after LPS and IL4 stimulation

• class switch recombination is largely direct instead of sequential

• endogenous Switch mu intraswitch recombination is reduced compared to in wild-type mice

increased IgE level ( J:201147 )

• in unchallenged mice

• 6-fold increase in IgE+ B cells in splenocyte cultures stimulated with LPS and IL4

• 4-fold increase in IgE+ cells in splenocyte cultures stimulated with LPS alone

• in mice in response to a variety of systemic and local challenges (TNP-OVA and infection with Nippostrongylus brasiliensis)

decreased IgG1 level ( J:201147 )

• 11-fold decrease in IgG1+ B cells in splenocyte cultures stimulated with LPS and IL4

decreased IgG3 level ( J:201147 )

• from splenocytes stimulated with LPS alone

Allelic Composition	Igh^tm1.1Vmd/Igh⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1.1Vmd mutation (0 available); any Igh mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:201147 )

• 3-fold reduction in class switch recombination in IgG1+ clones and 5-fold increase in IgE+ clones after LPS and IL4 stimulation

hematopoietic system

abnormal class switch recombination ( J:201147 )

• 3-fold reduction in class switch recombination in IgG1+ clones and 5-fold increase in IgE+ clones after LPS and IL4 stimulation

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