All Phenotypes Klf15<tm2Jain> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Apoe^tm1Unc/Apoe^tm1Unc Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0	involves: 129P2/OlaHsd * FVB/N	MGI:5552967
cn2	Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0	involves: FVB/N	MGI:5552966

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0 Apoe^tm1Unc/Apoe^tm1Unc aortas develop more atherosclerotic lesions after a high fat diet challenge

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:203920 )

N	• mice fed a high fat diet exhibit the same circulating levels of cholesterol and triglycerides as in Apoe^tm1Unc homozygotes

immune system

blood vessel inflammation ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

increased macrophage cell number ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

cardiovascular system

increased susceptibility to atherosclerosis ( J:203920 )

• in mice fed a high fat diet compared with Apoe^tm1Unc homozygotes

vascular smooth muscle hypoplasia ( J:203920 )

• decreased vascular smooth muscle cells in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

blood vessel inflammation ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

muscle

vascular smooth muscle hypoplasia ( J:203920 )

• decreased vascular smooth muscle cells in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

hematopoietic system

increased macrophage cell number ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

Allelic Composition	Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf15^tm2Jain mutation (0 available); any Klf15 mutation (21 available)
Tg(Tagln-cre)1Jjl mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:203920 )

N	• mice are viable and born in expected Mendelian ratios

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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