Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpntm2.1Mlkn mutation
(0 available);
any
Pdpn mutation
(28 available)
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
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VEGF-C-and galectin-8-induced lymphangiogenesis is diminished in Pdpntm2.1Mlkn/Pdpntm2.1Mlkn Tg(CAG-cre/Esr1*)5Amc/0 mice
immune system
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• in corneal micropocket assays, corneas implanted with either VEGF-C or galectin-8 pellets in tamoxifen-treated mice exhibit significantly reduced lymphangiogenesis relative to similarly-implanted wild-type corneas, as quantified by the lymphatic vessel area on day 7 post-surgery
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpntm2.1Mlkn mutation
(0 available);
any
Pdpn mutation
(28 available)
Rag1tm1Mom mutation
(49 available);
any
Rag1 mutation
(120 available)
Tg(Pdgfrb-cre)9Rha mutation
(1 available)
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immune system
cardiovascular system
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N |
• mice do not exhibit bleeding into mucosal lymph nodes unlike in Pdpntm2.1Mlkn/Pdpntm2.1Mlkn Tg(Pdgfrb-cre)9Rha mice
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hematopoietic system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpntm2.1Mlkn mutation
(0 available);
any
Pdpn mutation
(28 available)
Tg(Pdgfrb-cre)9Rha mutation
(1 available)
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cardiovascular system
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• bleeding in mucosal lymph nodes
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immune system
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• bleeding in mucosal lymph nodes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpntm2.1Mlkn mutation
(0 available);
any
Pdpn mutation
(28 available)
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
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cardiovascular system
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• mucosal high endothelial venule (HEV) junctions in tamoxifen-treated mice resemble those of reactive peripheral HEVs
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• beginning at P15, tamoxifen-treated mice exhibit massive bleeding primarily in mucosal lymph nodes (mesenteric and cervical) but rarely in peripheral (inguinal and popliteal) lymph nodes with extravasation of red blood cells around high endothelial venules
• ovalbumin and CFA challenged tamoxifen-treated mice develop bleeding in draining peripheral lymph nodes of tamoxifen-treated mice
• treatment with Mel-14 reduces bleeding in draining peripheral lymph nodes of tamoxifen-treated mice
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• extravasation of red blood cells around high endothelial venules (HEVs) in lymph nodes from tamoxifen-treated mice
• FITC-dextran leaks from HEVs in tamoxifen-treated mice
• however, non-HEV blood vessels in lymph nodes and other organs do not leak FITC-dextran
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immune system
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• loss of mucosal and peripheral lymph nodes in tamoxifen-treated mice
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• loss of mucosal and peripheral lymph nodes in tamoxifen-treated mice
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Analysis Tools