Phenotypes associated with this allele

• Allele Symbol: Vangl2^tm2.2Mdea
• Allele Name: targeted mutation 2.2, Michael R Deans
• Allele ID: MGI:5551990
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vangl2^tm2.2Mdea/Vangl2^tm2.2Mdea	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:5552007

Genotype
MGI:5552007

hm1

• Allelic Composition: Vangl2^tm2.2Mdea/Vangl2^tm2.2Mdea
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:201321 )

• mice are not viable because of neural tube defects

hearing/vestibular/ear

abnormal cochlea morphology ( J:201321 )

• short

abnormal orientation of inner hair cell stereociliary bundles ( J:201321 )

• misorientated

abnormal orientation of outer hair cell stereociliary bundles ( J:201321 )

• pointed in the wrong direction in the third outer hair cell row

short scala media ( J:201321 )

decreased cochlea coiling ( J:201321 )

• fewer turns than in wild-type mice

inner ear hypoplasia ( J:201321 )

• reduced in size dosroventrally

nervous system

abnormal neural tube morphology ( J:201321 )

• neural tube defects

abnormal orientation of inner hair cell stereociliary bundles ( J:201321 )

• misorientated

abnormal orientation of outer hair cell stereociliary bundles ( J:201321 )

• pointed in the wrong direction in the third outer hair cell row

embryo

abnormal neural tube morphology ( J:201321 )

• neural tube defects