All Phenotypes Wapl<tm1.2Jmpt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wapl^tm1.2Jmpt
targeted mutation 1.2, Jan-Michael Peters
MGI:5551807

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wapl^tm1.2Jmpt/Wapl^tm1.2Jmpt	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:5551814
cn2	Wapl^tm1.1Jmpt/Wapl^tm1.2Jmpt Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺	involves: 129 * C57BL/6 * C57BL/6NTac * SJL	MGI:5551813
cn3	Espl1^tm1.1Kna/Espl1^tm1.2Kna Wapl^tm1.1Jmpt/Wapl^tm1.2Jmpt Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL	MGI:5551815

Allelic Composition	Wapl^tm1.2Jmpt/Wapl^tm1.2Jmpt
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wapl^tm1.2Jmpt mutation (0 available); any Wapl mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:205429 )

• no mice are born from breeding heterozygotes

Allelic Composition	Wapl^tm1.1Jmpt/Wapl^tm1.2Jmpt Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/6NTac * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} mutation (3 available); any Gt(ROSA)26Sor mutation (1046 available)
Wapl^tm1.1Jmpt mutation (0 available); any Wapl mutation (169 available)
Wapl^tm1.2Jmpt mutation (0 available); any Wapl mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell cycle ( J:205429 )

• impaired cell cycle progression in tamoxifen-treated mouse embryonic cells with improper chromosome segregation

abnormal mitosis ( J:205429 )

• tamoxifen-treated mouse embryonic cells exhibit improper chromosome segregation

absent fibroblast proliferation ( J:205429 )

• in tamoxifen-treated mouse embryonic cells stimulated with serum

Allelic Composition	Espl1^tm1.1Kna/Espl1^tm1.2Kna Wapl^tm1.1Jmpt/Wapl^tm1.2Jmpt Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1^tm1.1Kna mutation (0 available); any Espl1 mutation (92 available)
Espl1^tm1.2Kna mutation (0 available); any Espl1 mutation (92 available)
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} mutation (3 available); any Gt(ROSA)26Sor mutation (1046 available)
Wapl^tm1.1Jmpt mutation (0 available); any Wapl mutation (169 available)
Wapl^tm1.2Jmpt mutation (0 available); any Wapl mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitosis ( J:205429 )

• tamoxifen-treated mouse embryonic fibroblasts exhibit diplo-chromosomes with unseparated arms unlike in control cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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