About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wapltm1.1Jmpt
targeted mutation 1.1, Jan-Michael Peters
MGI:5551791
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Wapltm1.1Jmpt/Wapltm1.2Jmpt
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: 129 * C57BL/6 * C57BL/6NTac * SJL MGI:5551813
cn2
 		Espl1tm1.1Kna/Espl1tm1.2Kna
Wapltm1.1Jmpt/Wapltm1.2Jmpt
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL MGI:5551815


Genotype
MGI:5551813
cn1
Allelic
Composition		 Wapltm1.1Jmpt/Wapltm1.2Jmpt
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Wapltm1.1Jmpt mutation (0 available); any Wapl mutation (168 available)
Wapltm1.2Jmpt mutation (0 available); any Wapl mutation (168 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:205429 )
• impaired cell cycle progression in tamoxifen-treated mouse embryonic cells with improper chromosome segregation
abnormal mitosis ( J:205429 )
• tamoxifen-treated mouse embryonic cells exhibit improper chromosome segregation
absent fibroblast proliferation ( J:205429 )
• in tamoxifen-treated mouse embryonic cells stimulated with serum




Genotype
MGI:5551815
cn2
Allelic
Composition		 Espl1tm1.1Kna/Espl1tm1.2Kna
Wapltm1.1Jmpt/Wapltm1.2Jmpt
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.1Kna mutation (0 available); any Espl1 mutation (95 available)
Espl1tm1.2Kna mutation (0 available); any Espl1 mutation (95 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Wapltm1.1Jmpt mutation (0 available); any Wapl mutation (168 available)
Wapltm1.2Jmpt mutation (0 available); any Wapl mutation (168 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitosis ( J:205429 )
• tamoxifen-treated mouse embryonic fibroblasts exhibit diplo-chromosomes with unseparated arms unlike in control cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory