Phenotypes associated with this allele

• Allele Symbol: Samhd1^{tm1d(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:5551758
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Samhd1^tm1d(EUCOMM)Wtsi/Samhd1^tm1d(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5551761

Genotype
MGI:5551761

hm1

• Allelic Composition: Samhd1^{tm1d(EUCOMM)Wtsi}/Samhd1^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0424_3_A06

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:202757 )

N • spontaneous IFN release does not result in autoimmune disease

abnormal response to infection ( J:202757 )

• bone marrow-derived dendritic cells, mouse embryonic fibroblasts, splenocytes, CD4+ T cells, CD8+ T cells, B cells and dendritic cells exhibit increased cellular dNTP concentrations and increased retroviral replication compared with wild-type cells

• replication of HIV-1 is increased in CD3+ T cells, B cells, dendritic cells and macrophages compared with wild-type cells

• however, Friend leukemia virus replication is normal

cellular

abnormal cell physiology ( J:202757 )

• mouse embryonic fibroblasts, bone marrow-derived dendritic cells, macrophages, B cells and T cells exhibit increased cellular dNTP concentrations compared with control cells