Phenotypes associated with this allele

• Allele Symbol: Klf5^tm1.1Jtd
• Allele Name: targeted mutation 1.1, Jin-Tang Dong
• Allele ID: MGI:5551641
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf5^tm1.1Jtd/Klf5^tm1.1Jtd	involves: C57BL/6	MGI:5551714
cn2	Klf5^tm1.1Jtd/Klf5^tm1.1Jtd Tg(Pbsn-cre)4Prb/0	involves: C57BL/6 * DBA/2	MGI:5551715
cn3	Klf5^tm1.1Jtd/Klf5^+ Tg(Pbsn-cre)4Prb/0	involves: C57BL/6 * DBA/2	MGI:5551716

Genotype
MGI:5551714

hm1

• Allelic Composition: Klf5^tm1.1Jtd/Klf5^tm1.1Jtd
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:206639 )

• mice are viable and fertile and do not display any gross physical or behavioral abnormalities

Genotype
MGI:5551715

cn2

• Allelic Composition: Klf5^tm1.1Jtd/Klf5^tm1.1Jtd; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: C57BL/6 * DBA/2

Abnormal prostate morphology in Klf5^tm1.1Jtd/Klf5⁺ Tg(Pbsn-cre)4Prb/0 and Klf5^tm1.1Jtd/Klf5^tm1.1Jtd Tg(Pbsn-cre)4Prb/0 males

reproductive system

decreased prostate gland weight ( J:206639 )

• increased castration-induced shrinkage of the prostate

• however, administration of androgen restores weight

prostate gland hyperplasia ( J:206639 )

• benign

abnormal prostate gland physiology ( J:206639 )

• increased cell apoptosis compared to in Klf5^tm1.1Jtd/Klf5⁺ Tg(Pbsn-cre)4Prb mice and mice with wild-type alleles

neoplasm

neoplasm ( J:206639 )

N • at 1 and 2 years, mice do not develop increased incidence of prostatic intraepithelial neoplasia

endocrine/exocrine glands

decreased prostate gland weight ( J:206639 )

• increased castration-induced shrinkage of the prostate

• however, administration of androgen restores weight

prostate gland hyperplasia ( J:206639 )

• benign

abnormal prostate gland physiology ( J:206639 )

• increased cell apoptosis compared to in Klf5^tm1.1Jtd/Klf5⁺ Tg(Pbsn-cre)4Prb mice and mice with wild-type alleles

Genotype
MGI:5551716

cn3

• Allelic Composition: Klf5^tm1.1Jtd/Klf5⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: C57BL/6 * DBA/2

Abnormal prostate morphology in Klf5^tm1.1Jtd/Klf5⁺ Tg(Pbsn-cre)4Prb/0 and Klf5^tm1.1Jtd/Klf5^tm1.1Jtd Tg(Pbsn-cre)4Prb/0 males

reproductive system

abnormal prostate gland anterior lobe morphology ( J:206639 )

• thick cell layers

abnormal prostate gland dorsolateral lobe morphology ( J:206639 )

• thick cell layers

decreased prostate gland weight ( J:206639 )

• increased castration-induced shrinkage of the prostate

• however, administration of androgen restores weight

prostate gland hyperplasia ( J:206639 )

• more severe than in Klf5^tm1.1Jtd/Klf5^tm1.1Jtd Tg(Pbsn-cre)4Prb mice

abnormal prostate gland physiology ( J:206639 )

• increased cell proliferation compared to in Klf5^tm1.1Jtd/Klf5^tm1.1Jtd Tg(Pbsn-cre)4Prb mice and mice with wild-type alleles

neoplasm

neoplasm ( J:206639 )

N • at 1 and 2 years, mice do not develop increased incidence of prostatic intraepithelial neoplasia

endocrine/exocrine glands

abnormal prostate gland anterior lobe morphology ( J:206639 )

• thick cell layers

abnormal prostate gland dorsolateral lobe morphology ( J:206639 )

• thick cell layers

decreased prostate gland weight ( J:206639 )

• increased castration-induced shrinkage of the prostate

• however, administration of androgen restores weight

prostate gland hyperplasia ( J:206639 )

• more severe than in Klf5^tm1.1Jtd/Klf5^tm1.1Jtd Tg(Pbsn-cre)4Prb mice

abnormal prostate gland physiology ( J:206639 )

• increased cell proliferation compared to in Klf5^tm1.1Jtd/Klf5^tm1.1Jtd Tg(Pbsn-cre)4Prb mice and mice with wild-type alleles