Phenotypes associated with this allele

• Allele Symbol: Kdm6b^tm1.1Iwam
• Allele Name: targeted mutation 1.1, Naoki Iwamori
• Allele ID: MGI:5551613
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kdm6b^tm1.1Iwam/Kdm6b^tm1.2Iwam Tg(Stra8-icre)1Reb/0	involves: 129P2/OlaHsd * C57BL/6J * FVB/NJ	MGI:5551619

Genotype
MGI:5551619

cn1

• Allelic Composition: Kdm6b^tm1.1Iwam/Kdm6b^tm1.2Iwam; Tg(Stra8-icre)1Reb/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Enlarged testes in Kdm6b^tm1.1Iwam/Kdm6b^tm1.2Iwam Tg(Stra8-icre)1Reb/0 males

cellular

abnormal spermatogonia morphology ( J:206350 )

♂ • increased Asingle spermatogonia in seminiferous tubules

♂ • frequent spermatogonial dedifferentiation

reproductive system

abnormal spermatogonia morphology ( J:206350 )

♂ • increased Asingle spermatogonia in seminiferous tubules

♂ • frequent spermatogonial dedifferentiation

enlarged testis ( J:206350 )

♂

delayed reproductive senescence ( J:206350 )

♂ • male mice sire pups much longer without a change in litter size compared with wild-type mice

♂ • however, litter production rate is normal

enhanced male fertility ( J:206350 )

♂ • male mice sire pups much longer without a change in litter size compared with wild-type mice

♂ • however, litter production rate is normal

endocrine/exocrine glands

enlarged testis ( J:206350 )

♂