About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mfap5tm1Mech
targeted mutation 1, Robert P Mecham
MGI:5551608
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mfap5tm1Mech/Mfap5tm1Mech Not Specified MGI:5551609
cx2
 		Mfap2tm1Mech/Mfap2tm1Mech
Mfap5tm1Mech/Mfap5tm1Mech 		involves: 129X1/SvJ MGI:5551611


Genotype
MGI:5551609
hm1
Allelic
Composition		 Mfap5tm1Mech/Mfap5tm1Mech
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfap5tm1Mech mutation (0 available); any Mfap5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:203960 )
N
• mice exhibit normal monocyte and macrophage counts

cardiovascular system
cardiovascular system phenotype ( J:203960 )
N
• mice exhibit normal blood pressure and heart weight

skeleton
skeleton phenotype ( J:203960 )
N
• mice exhibit normal bone mass and architecture

hematopoietic system




Genotype
MGI:5551611
cx2
Allelic
Composition		 Mfap2tm1Mech/Mfap2tm1Mech
Mfap5tm1Mech/Mfap5tm1Mech
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfap2tm1Mech mutation (0 available); any Mfap2 mutation (15 available)
Mfap5tm1Mech mutation (0 available); any Mfap5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal compact bone morphology ( J:203960 )
• reduced medullary volume
abnormal compact bone volume ( J:203960 )
• increased bone volume fraction in cortical bone due to reduced marrow cavity

immune system
immune system phenotype ( J:203960 )
N
• mice exhibit normal macrophage counts

cardiovascular system
cardiovascular system phenotype ( J:203960 )
N
• mice exhibit normal blood pressure and heart weight
abnormal aorta morphology ( J:203960 )
• increased outer diameter at physiological pressures at 6 months

hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory