About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxf1tm2Rhc
targeted mutation 2, Robert H Costa
MGI:5550485
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Foxf1tm2Rhc/Foxf1tm2Rhc
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: C57BL/6 * DBA/2 MGI:5550501
cn2
 		Foxf1tm2Rhc/Foxf1+
Tg(Myh11-cre,-EGFP)2Mik/0 		involves: C57BL/6 * DBA/2 MGI:5550502


Genotype
MGI:5550501
cn1
Allelic
Composition		 Foxf1tm2Rhc/Foxf1tm2Rhc
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxf1tm2Rhc mutation (0 available); any Foxf1 mutation (14 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:203847 )
• mice die prior to or immediately after birth

digestive/alimentary system
dilated esophagus ( J:203847 )
• distended esophagus

muscle




Genotype
MGI:5550502
cn2
Allelic
Composition		 Foxf1tm2Rhc/Foxf1+
Tg(Myh11-cre,-EGFP)2Mik/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxf1tm2Rhc mutation (0 available); any Foxf1 mutation (14 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality, incomplete penetrance ( J:203847 )
• no time point given

muscle
abnormal intestinal smooth muscle morphology ( J:203847 )
• slight decreased thickness of the circular smooth muscle layer in the colon
impaired contractility of intestinal smooth muscle ( J:203847 )
• impaired depolarization induced contractility of colonic rings

digestive/alimentary system
abnormal intestinal smooth muscle morphology ( J:203847 )
• slight decreased thickness of the circular smooth muscle layer in the colon




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory