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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hivep3tm3Glm
targeted mutation 3, Laurie H Glimcher
MGI:5550463
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hivep3tm3Glm/Hivep3+
Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Tg(Prrx1-cre)1Cjt/0 		involves: 129 * C57BL/6J * SJL * SJL/J MGI:5550510
cn2
 		Hivep3tm3Glm/Hivep3tm3Glm
Tg(Prrx1-cre)1Cjt/0 		involves: C57BL/6 * C57BL/6J * SJL/J MGI:5550518


Genotype
MGI:5550510
cn1
Allelic
Composition		 Hivep3tm3Glm/Hivep3+
Map2k1tm1Chrn/Map2k1tm1Chrn
Map2k2tm1Chrn/Map2k2tm1Chrn
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129 * C57BL/6J * SJL * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3tm3Glm mutation (0 available); any Hivep3 mutation (106 available)
Map2k1tm1Chrn mutation (1 available); any Map2k1 mutation (94 available)
Map2k2tm1Chrn mutation (1 available); any Map2k2 mutation (34 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton




Genotype
MGI:5550518
cn2
Allelic
Composition		 Hivep3tm3Glm/Hivep3tm3Glm
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hivep3tm3Glm mutation (0 available); any Hivep3 mutation (106 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal skeleton physiology ( J:184764 )
• bones exhibit improved performance in biomechanical testing (decreased indentation distance increase decreased mean energy dissipated and increased unloading stiffness) compared with control bones




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory