Phenotypes associated with this allele

• Allele Symbol: Prps1^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548962
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prps1^tm1b(EUCOMM)Wtsi/Prps1^tm1b(EUCOMM)Wtsi	C57BL/6N-Prps1^tm1b(EUCOMM)Wtsi/Ics	MGI:6480560
ht2	Prps1^tm1b(EUCOMM)Wtsi/Prps1^+	C57BL/6N-Prps1^tm1b(EUCOMM)Wtsi/Ics	MGI:5757574

Genotype
MGI:6480560

hm1

• Allelic Composition: Prps1^{tm1b(EUCOMM)Wtsi}/Prps1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Prps1^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0436_5_D08

Data Sources

IMPC Data for Prps1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - ICS

Genotype
MGI:5757574

ht2

• Allelic Composition: Prps1^{tm1b(EUCOMM)Wtsi}/Prps1⁺
• Genetic Background: C57BL/6N-Prps1^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0436_5_D08

Data Sources

IMPC Data for Prps1

hematopoietic system

increased neutrophil cell number ( J:211773 )

♀

IMPC - ICS

decreased lymphocyte cell number ( J:211773 )

♀

IMPC - ICS

homeostasis/metabolism

increased circulating total protein level ( J:211773 )

♀

IMPC - ICS

immune system

increased neutrophil cell number ( J:211773 )

♀

IMPC - ICS

decreased lymphocyte cell number ( J:211773 )

♀

IMPC - ICS