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Allele Symbol Allele Name Allele ID |
Synmtm1.1(KOMP)Vlcg targeted mutation 1.1, Velocigene MGI:5548847 |
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| Summary |
2 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 31% increase in the mass of 12 month old hearts
• however, heart muscles show normal sarcomere and costamere architecture
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• modest enlargement of cardiomyocytes at 12 months of age
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• in 12 month old mice
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• hearts show modest hypertrophy including a 20% increase in the number of nuclei at 12 months
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• old hearts have greater left ventricle mass, suggesting left ventricle myocardial hypertrophy
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• old hearts have greater left ventricle mass, suggesting left ventricle myocardial hypertrophy
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• young hearts show lower left ventricle posterior wall thickness
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• old hearts have lower left ventricle fractional shortening and left ventricle ejection fraction and greater left ventricle end-diastolic dimension and greater left ventricular dimension during diastole, indicating left ventricle dilation
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• hearts show a small increase in fibrosis at 12 months of age
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• 12 month old mice show decreased cardiac output
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• 12 month old mice show decreased stroke volume
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• young (3 months) and old (12 months) hearts have lower left ventricle fractional shortening and left ventricle ejection fraction, indicating decreased left ventricle contractility
• PV loop studies of 3 month old mice show lower left ventricle ejection fraction, maximal rate of left ventricular pressure rise (+dP/dt), slope of left ventricular end-systolic pressure-volume relationship (Ees), preload recruitable stroke work (PRSW), and +dp/dt-end-diastolic pressure, indicating impaired left ventricular systolic function
• PV loops studies of 12 month old mice show significant increases in left ventricle end diastolic pressure and decreases in Ees, PRSW, +dP/dt-EDP and left ventricle ejection fraction
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• echocardiography shows that young (3 months) and old (12 months) hearts have greater left ventricular dimension during systole and decreased left ventricle fractional shortening and ejection fraction
• echocardiogarphy shows that old hearts also exhibit increased left ventricular dimension during diastole and left ventricle mass
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• heart rate is increased in 12 month old mice compared to 3 month old mice
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• in response to contractions elicited by action potentials under no-load conditions, cardiomyocytes from 3 and 12 month old mice show a decrease in the magnitude of sarcomeric shortening and in the rate of shortening, however relaxation is normal
• cardiomyocytes from 12 month, but not 3 month old mice, show a decrease in the calcium transient amplitude
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• 12 month old hearts show patterns of hypertrophic cardiomyopathy
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• old hearts have greater left ventricle mass, suggesting left ventricle myocardial hypertrophy
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• old hearts have greater left ventricle mass, suggesting left ventricle myocardial hypertrophy
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• more fibers with centrally located nuclei in tibialis anterior and extensor digitorum longus
• contractile apparatus appears normal
• sarcolemma, costamere, associated myofibrils are more deformable than in controls
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• modest enlargement of cardiomyocytes at 12 months of age
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• separation of sarcolemma from myofibrils occurs more readily
• sarcolemma is less stable
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• tibialis anterior muscle is more susceptible to loss of function due to injury caused by lengthening contractions
• more necrotic fibers are found three days after injury than are found in controls
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• significantly reduced muscle mass of the tibialis anterior
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• smaller diameter of tibialis anterior and quadriceps muscle but normal size for extensor digitorum longus and soleus
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• young (3 months) and old (12 months) hearts have lower left ventricle fractional shortening and left ventricle ejection fraction, indicating decreased left ventricle contractility
• PV loop studies of 3 month old mice show lower left ventricle ejection fraction, maximal rate of left ventricular pressure rise (+dP/dt), slope of left ventricular end-systolic pressure-volume relationship (Ees), preload recruitable stroke work (PRSW), and +dp/dt-end-diastolic pressure, indicating impaired left ventricular systolic function
• PV loops studies of 12 month old mice show significant increases in left ventricle end diastolic pressure and decreases in Ees, PRSW, +dP/dt-EDP and left ventricle ejection fraction
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• 12 month old hearts show patterns of hypertrophic cardiomyopathy
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• fatigue increases relative to controls later in testing but is similar to controls earlier in testing
• ability to run uphill on a treadmill is less than controls but not significantly
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• 25% decrease in twitch specific force in isolated tibialis anterior fibers
• tetanic contractions less significantly affected
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• in 12 month old mice
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• hearts show modest hypertrophy including a 20% increase in the number of nuclei at 12 months
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• old hearts have greater left ventricle mass, suggesting left ventricle myocardial hypertrophy
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• old hearts have greater left ventricle mass, suggesting left ventricle myocardial hypertrophy
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• in 12 month old mice
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• tibialis anterior muscle is more susceptible to loss of function due to injury caused by lengthening contractions
• more necrotic fibers are found three days after injury than are found in controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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