Phenotypes associated with this allele

• Allele Symbol: Nubpl^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548675
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nubpl^tm1b(KOMP)Wtsi/Nubpl^tm1b(KOMP)Wtsi	C57BL/6N-Nubpl^tm1b(KOMP)Wtsi/Wtsi	MGI:5757440

Genotype
MGI:5757440

hm1

• Allelic Composition: Nubpl^{tm1b(KOMP)Wtsi}/Nubpl^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Nubpl^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0216_2_C03

Data Sources

IMPC Data for Nubpl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal placenta morphology ( J:261316 )

• branching morphology defect

abnormal trophoblast layer morphology ( J:261316 )

• size of the trophoblast compartment is reduced

• biased differentiation (diploid/polyploid trophoblast)

abnormal trophoblast giant cell morphology ( J:261316 )

• abnormal trophoblast giant cell size and morphology

mortality/aging

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - WTSI

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

embryonic lethality during organogenesis, complete penetrance ( J:261316 )

• lethality at E9.5-E10.5