Phenotypes associated with this allele

• Allele Symbol: Exoc3l2^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548646
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Exoc3l2^tm1b(KOMP)Wtsi/Exoc3l2^tm1b(KOMP)Wtsi	C57BL/6N-Exoc3l2^tm1b(KOMP)Wtsi/Wtsi	MGI:5757064
ht2	Exoc3l2^tm1b(KOMP)Wtsi/Exoc3l2^+	C57BL/6N-Exoc3l2^tm1b(KOMP)Wtsi/Wtsi	MGI:5757063

Genotype
MGI:5757064

hm1

• Allelic Composition: Exoc3l2^{tm1b(KOMP)Wtsi}/Exoc3l2^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Exoc3l2^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0331_5_B02

Data Sources

IMPC Data for Exoc3l2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

dilated liver sinusoidal space ( J:239583 )

DMDD

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5

abnormal ductus venosus valve topology ( J:239583 )

DMDD

embryo

abnormal placenta morphology ( J:261316 )

• reduced cellular density of placenta at E14.5

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5

liver/biliary system

dilated liver sinusoidal space ( J:239583 )

DMDD

herniated liver ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 , J:261316 )

IMPC - WTSI (J:211773)

MGI

• lethality at P14, with viable fetuses at E14.5 (J:261316)

Genotype
MGI:5757063

ht2

• Allelic Composition: Exoc3l2^{tm1b(KOMP)Wtsi}/Exoc3l2⁺
• Genetic Background: C57BL/6N-Exoc3l2^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0331_5_B02

Data Sources

IMPC Data for Exoc3l2

homeostasis/metabolism

increased circulating iron level ( J:211773 )

♀

IMPC - WTSI