Phenotypes associated with this allele

• Allele Symbol: Tmem106b^{tm2b(KOMP)Wtsi}
• Allele Name: targeted mutation 2b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548613
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem106b^tm2b(KOMP)Wtsi/Tmem106b^tm2b(KOMP)Wtsi	C57BL/6N-Tmem106b^tm2b(KOMP)Wtsi/Ucd	MGI:5757813
hm2	Tmem106b^tm2b(KOMP)Wtsi/Tmem106b^tm2b(KOMP)Wtsi	involves: C57BL/6N	MGI:6512376

Genotype
MGI:5757813

hm1

• Allelic Composition: Tmem106b^{tm2b(KOMP)Wtsi}/Tmem106b^{tm2b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Tmem106b^{tm2b(KOMP)Wtsi}/Ucd
• Cell Lines: EPD0047_1_E02

Data Sources

IMPC Data for Tmem106b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body length ( J:211773 )

IMPC - UCD

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - UCD

nervous system

decreased brain weight ( J:211773 )

♂

IMPC - UCD

reproductive system

abnormal epididymis morphology ( J:211773 )

♂

IMPC - UCD

enlarged epididymis ( J:211773 )

♂

IMPC - UCD

skeleton

increased bone mineral content ( J:211773 )

IMPC - UCD

Genotype
MGI:6512376

hm2

• Allelic Composition: Tmem106b^{tm2b(KOMP)Wtsi}/Tmem106b^{tm2b(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N

nervous system

spongiform encephalopathy ( J:288278 )

• spongiform vacuolization of selected brain areas (facial motor nucleus (FMN), subregions of thalamus, trigeminal motor nucleus) at age 6 months