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Allele Symbol Allele Name Allele ID |
Inf2tm1.1(KOMP)Vlcg targeted mutation 1.1, Velocigene MGI:5548597 |
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| Summary |
2 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decrease in the number of maternal spiral arteries at E19.0
• fetal vascular density is increased in the labyrinth at E18.5
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• the proportion of placental depth consisting of labyrinth but not junctional zone is significantly reduced
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• decrease in the number of maternal spiral arteries at E19.0
• fetal vascular density is increased in the labyrinth at E18.5
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• increased blood pressure in pregnant females at day 17.5
• however at day 15.5 and postpartum day 2 blood pressure is similar to controls
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• in the fetal umbilical artery end-diastolic velocity and pulsatility index are significantly elevated in fetuses at E18.5
• at E18.5, some umbilical vein waveforms appear pulsatile
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• at E18.5; however, birth weight is similar to controls
• ratio of fetal to placental weight is reduced
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• significantly growth restricted at E18.5
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• gestation length is increased by 9.8 h compared to wild-type controls
• but pup weight, litter size and total litter weight are similar to wild-type controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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