Phenotypes associated with this allele

• Allele Symbol: Ndufa8^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5548563
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ndufa8^tm1b(EUCOMM)Hmgu/Ndufa8^tm1b(EUCOMM)Hmgu	C57BL/6N-Ndufa8^tm1b(EUCOMM)Hmgu/Ieg	MGI:5757407
ht2	Ndufa8^tm1b(EUCOMM)Hmgu/Ndufa8^+	C57BL/6N-Ndufa8^tm1b(EUCOMM)Hmgu/Ieg	MGI:5757406

Genotype
MGI:5757407

hm1

• Allelic Composition: Ndufa8^{tm1b(EUCOMM)Hmgu}/Ndufa8^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Ndufa8^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0509_8_C03

Data Sources

IMPC Data for Ndufa8

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HMGU

Genotype
MGI:5757406

ht2

• Allelic Composition: Ndufa8^{tm1b(EUCOMM)Hmgu}/Ndufa8⁺
• Genetic Background: C57BL/6N-Ndufa8^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0509_8_C03

Data Sources

IMPC Data for Ndufa8

cardiovascular system

abnormal retina blood vessel morphology ( J:211773 )

♀

IMPC - HMGU

increased heart rate variability ( J:211773 )

♂

IMPC - HMGU

prolonged RR interval ( J:211773 )

♂

IMPC - HMGU

skeleton

increased bone mineral content ( J:211773 )

♀

IMPC - HMGU

vision/eye

abnormal retina blood vessel morphology ( J:211773 )

♀

IMPC - HMGU

abnormal lens morphology ( J:211773 )

IMPC - HMGU

decreased total retina thickness ( J:211773 )

IMPC - HMGU