Phenotypes associated with this allele

• Allele Symbol: Lsm1^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5548536
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lsm1^tm1b(EUCOMM)Hmgu/Lsm1^tm1b(EUCOMM)Hmgu	C57BL/6N-Lsm1^tm1b(EUCOMM)Hmgu/Ieg	MGI:5757322
ht2	Lsm1^tm1b(EUCOMM)Hmgu/Lsm1^+	C57BL/6N-Lsm1^tm1b(EUCOMM)Hmgu/Ieg	MGI:5757321

Genotype
MGI:5757322

hm1

• Allelic Composition: Lsm1^{tm1b(EUCOMM)Hmgu}/Lsm1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Lsm1^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0702_3_G05

Data Sources

IMPC Data for Lsm1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:211773 )

♂

IMPC - HMGU

decreased locomotor activity ( J:211773 )

IMPC - HMGU

hyperactivity ( J:211773 )

IMPC - HMGU

cardiovascular system

dilated aorta ( J:211773 )

♀

IMPC - HMGU

increased heart rate variability ( J:211773 )

♂

IMPC - HMGU

prolonged RR interval ( J:211773 )

♂

IMPC - HMGU

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - HMGU

hematopoietic system

increased mean corpuscular volume ( J:211773 )

♀

IMPC - HMGU

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - HMGU

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

♂

IMPC - HMGU

cataract ( J:211773 )

IMPC - HMGU

Genotype
MGI:5757321

ht2

• Allelic Composition: Lsm1^{tm1b(EUCOMM)Hmgu}/Lsm1⁺
• Genetic Background: C57BL/6N-Lsm1^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0702_3_G05

Data Sources

IMPC Data for Lsm1

behavior/neurological

increased grip strength ( J:211773 )

♂

IMPC - HMGU

cardiovascular system

dilated aorta ( J:211773 )

IMPC - HMGU

thick ventricular wall ( J:211773 )

IMPC - HMGU

increased heart rate variability ( J:211773 )

♂

IMPC - HMGU

homeostasis/metabolism

increased circulating sodium level ( J:211773 )

♀

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

IMPC - HMGU