Phenotypes associated with this allele

• Allele Symbol: Fgf10^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5548400
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf10^tm1b(EUCOMM)Wtsi/Fgf10^tm1b(EUCOMM)Wtsi	C57BL/6N-Fgf10^tm1b(EUCOMM)Wtsi/H	MGI:5757113
ht2	Fgf10^tm1b(EUCOMM)Wtsi/Fgf10^+	C57BL/6N-Fgf10^tm1b(EUCOMM)Wtsi/H	MGI:5757112

Genotype
MGI:5757113

hm1

• Allelic Composition: Fgf10^{tm1b(EUCOMM)Wtsi}/Fgf10^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Fgf10^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0378_4_A02

Data Sources

IMPC Data for Fgf10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - HAR

Genotype
MGI:5757112

ht2

• Allelic Composition: Fgf10^{tm1b(EUCOMM)Wtsi}/Fgf10⁺
• Genetic Background: C57BL/6N-Fgf10^{tm1b(EUCOMM)Wtsi}/H
• Cell Lines: EPD0378_4_A02

Data Sources

IMPC Data for Fgf10

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - HAR

behavior/neurological

abnormal behavior ( J:211773 )

♀

IMPC - HAR

decreased thigmotaxis ( J:211773 )

♀

IMPC - HAR

impaired pupillary reflex ( J:211773 )

♀

IMPC - HAR

decreased grip strength ( J:211773 )

♀

IMPC - HAR

decreased locomotor activity ( J:211773 )

♀

IMPC - HAR

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

♀

IMPC - HAR

abnormal retina blood vessel morphology ( J:211773 )

♀

IMPC - HAR

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - HAR

hematopoietic system

decreased leukocyte cell number ( J:211773 )

♂

IMPC - HAR

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

IMPC - HAR

increased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - HAR

immune system

decreased leukocyte cell number ( J:211773 )

♂

IMPC - HAR

nervous system

abnormal optic disk morphology ( J:211773 )

♀

IMPC - HAR

pigmentation

abnormal iris pigmentation ( J:211773 )

♀

IMPC - HAR

vision/eye

impaired pupillary reflex ( J:211773 )

♀

IMPC - HAR

abnormal retina vasculature morphology ( J:211773 )

♀

IMPC - HAR

abnormal retina blood vessel morphology ( J:211773 )

♀

IMPC - HAR

abnormal optic disk morphology ( J:211773 )

♀

IMPC - HAR

abnormal iris pigmentation ( J:211773 )

♀

IMPC - HAR

abnormal placement of pupils ( J:211773 )

♀

IMPC - HAR

iris synechia ( J:211773 )

♀

IMPC - HAR

abnormal cornea morphology ( J:211773 )

♀

IMPC - HAR

corneal opacity ( J:211773 )

♀

IMPC - HAR

abnormal lens morphology ( J:211773 )

♀

IMPC - HAR

fused cornea and lens ( J:211773 )

♀

IMPC - HAR

cataract ( J:211773 )

♀

IMPC - HAR

persistence of hyaloid vascular system ( J:211773 )

♀

IMPC - HAR

narrow eye opening ( J:211773 )

IMPC - HAR