Phenotypes associated with this allele

• Allele Symbol: Kmt2a^tm1.1Jjdh
• Allele Name: targeted mutation 1.1, James J Hsieh
• Allele ID: MGI:5548103
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kmt2a^tm1.1Jjdh/Kmt2a^tm1.1Jjdh	B6.129X1-Kmt2a^tm1.1Jjdh	MGI:5548112
hm2	Kmt2a^tm1.1Jjdh/Kmt2a^tm1.1Jjdh	involves: 129X1/SvJ	MGI:5565087
cx3	Kmt2a^tm1.1Jjdh/Kmt2a^tm1.1Jjdh Kmt2b^tm1Jjdh/Kmt2b^tm1Jjdh	involves: 129X1/SvJ	MGI:5565088

Genotype
MGI:5548112

hm1

• Allelic Composition: Kmt2a^tm1.1Jjdh/Kmt2a^tm1.1Jjdh
• Genetic Background: B6.129X1-Kmt2a^tm1.1Jjdh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

sternebra fusion ( J:201612 )

• incomplete segmentation between sternebra 3 and 4 in 3 of 10 mice

abnormal arcus anterior morphology ( J:201612 )

• deformed anterior arch of atlas in 4 of 10 mice compared with 2 of 10 wild-type mice

nervous system

glossopharyngeal nerve hypoplasia ( J:201612 )

• with outgrowth defects

growth/size/body

decreased body size ( J:201612 )

• slightly

Genotype
MGI:5565087

hm2

• Allelic Composition: Kmt2a^tm1.1Jjdh/Kmt2a^tm1.1Jjdh
• Genetic Background: involves: 129X1/SvJ

cellular

decreased fibroblast proliferation ( J:112159 )

• in MEFs

Genotype
MGI:5565088

cx3

• Allelic Composition: Kmt2a^tm1.1Jjdh/Kmt2a^tm1.1Jjdh; Kmt2b^tm1Jjdh/Kmt2b^tm1Jjdh
• Genetic Background: involves: 129X1/SvJ

cellular

decreased fibroblast proliferation ( J:112159 )

• in MEFs, decrease is more severe than in Kmt2a^tm1.1Jjdh single homozygotes

reproductive system

reproductive system phenotype ( J:205038 )

♂N • males are fertile with normal testes morphology