All Phenotypes Pax7<tm1.1Thbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pax7^tm1.1Thbr
targeted mutation 1.1, Thomas Braun
MGI:5548068

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pax7^tm1.1Thbr/Pax7^tm1.1Thbr	Not Specified	MGI:5548072
cn2	Pax7^tm1.1Thbr/Pax7^{tm2.1(cre/ERT2)Fan}	involves: 129S1/Sv * 129X1/SvJ	MGI:5548071
cn3	Pax7^tm1.1Thbr/Pax7^tm1.1Thbr Myf5^tm1(cre)Mrc/Myf5⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:5548073
cn4	Myf5^tm1(cre)Mrc/Myf5⁺ Myod1^tm1Jae/Myod1^tm1Jae Pax7^tm1.1Thbr/Pax7^tm1.1Thbr	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	MGI:5548074
cn5	Pax7^tm1.1Thbr/Pax7^tm1.1Thbr Myf5^tm3(cre)Sor/Myf5⁺	involves: 129S4/SvJaeSor	MGI:5548075
cn6	Pax7^tm1.1Thbr/Pax7^tm1.1Thbr Tg(CMV-cre)1Cgn/0	involves: BALB/cJ	MGI:5548070

Allelic Composition	Pax7^tm1.1Thbr/Pax7^tm1.1Thbr
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7^tm1.1Thbr mutation (0 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal skeletal muscle satellite cell proliferation ( J:202693 )

• reduced in cultures treated with a cre-expressing adenovirus

cellular

abnormal skeletal muscle satellite cell proliferation ( J:202693 )

• reduced in cultures treated with a cre-expressing adenovirus

Allelic Composition	Pax7^tm1.1Thbr/Pax7^{tm2.1(cre/ERT2)Fan}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7^tm1.1Thbr mutation (0 available); any Pax7 mutation (39 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:202693 )

N	• tamoxifen-treated mice do not exhibit centrally localized nuclei or differences in fiber diameter

abnormal skeletal muscle satellite cell proliferation ( J:202693 )

• reduced in tamoxifen-treated cultures

abnormal skeletal muscle morphology ( J:202693 )

• adult mice treated with tamoxifen exhibit rare atypical satellite cells with reduced heterochromatin condensation compared with control mice

decreased skeletal muscle size ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit reduced total muscle size compared with control mice

decreased satellite cell number ( J:202693 )

• after tamoxifen treatment

• after tamoxifen- and cardiotoxin-treatment

skeletal muscle fibrosis ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit massive increase in necrotic fibers and fibrotic tissue compared with control mice

skeletal muscle necrosis ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit massive increase in necrotic fibers and fibrotic tissue compared with control mice

abnormal muscle regeneration ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit reduced total muscle size and myofiber diameters with massive increase in necrotic fibers and fibrotic tissue compared with control mice

cellular

abnormal skeletal muscle satellite cell proliferation ( J:202693 )

• reduced in tamoxifen-treated cultures

Allelic Composition	Pax7^tm1.1Thbr/Pax7^tm1.1Thbr Myf5^tm1(cre)Mrc/Myf5⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1(cre)Mrc mutation (1 available); any Myf5 mutation (18 available)
Pax7^tm1.1Thbr mutation (0 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

decreased satellite cell number ( J:202693 )

• at day 110

Allelic Composition	Myf5^tm1(cre)Mrc/Myf5⁺ Myod1^tm1Jae/Myod1^tm1Jae Pax7^tm1.1Thbr/Pax7^tm1.1Thbr
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm1(cre)Mrc mutation (1 available); any Myf5 mutation (18 available)
Myod1^tm1Jae mutation (2 available); any Myod1 mutation (26 available)
Pax7^tm1.1Thbr mutation (0 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

decreased satellite cell number ( J:202693 )

• more so than in Pax7^tm1.1Thbr/Pax7^tm1.1Thbr Myf5^tm1(cre)Mrc/Myf5⁺ mice at day 110

Allelic Composition	Pax7^tm1.1Thbr/Pax7^tm1.1Thbr Myf5^tm3(cre)Sor/Myf5⁺
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5^tm3(cre)Sor mutation (1 available); any Myf5 mutation (18 available)
Pax7^tm1.1Thbr mutation (0 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

decreased skeletal muscle fiber diameter ( J:202693 )

• few thin myotubes following treatment with cardiotoxin

decreased skeletal muscle fiber number ( J:202693 )

• few thin myotubes following treatment with cardiotoxin

decreased satellite cell number ( J:202693 )

• in mice older than 56 days

• however, satellite cell numbers 10 weeks are normal

impaired skeletal muscle regeneration ( J:202693 )

• severe impairment following treatment with cardiotoxin at days 56, 90 and 315

growth/size/body

decreased body size ( J:202693 )

Allelic Composition	Pax7^tm1.1Thbr/Pax7^tm1.1Thbr Tg(CMV-cre)1Cgn/0
Genetic Background	involves: BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7^tm1.1Thbr mutation (0 available); any Pax7 mutation (39 available)
Tg(CMV-cre)1Cgn mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle morphology ( J:202693 )

• authors state that mice phenocopy Pax7^tm2Pgr homozygotes

decreased satellite cell number ( J:202693 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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