All Phenotypes Carmil2<bas> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Carmil2^bas/Carmil2^bas	involves: C3HeB/FeJ * C57BL/6	MGI:5547583
ht2	Carmil2^bas/Carmil2^{tm1a(KOMP)Mbp}	involves: C3HeB/FeJ * C57BL/6 * C57BL/6N	MGI:5547581
cx3	Lat^tm9Mal/Lat^tm9Mal Carmil2^bas/Carmil2^bas	involves: C3HeB/FeJ * C57BL/6	MGI:5547582

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:205441 )

N	• mice exhibit normal T cell development, positive selection, negative selection and CD28-independent TCR signaling

decreased T cell proliferation ( J:205441 )

• T cell proliferation fails to respond in a synergistic way to anti-CD3 and anti-CD28 antibodies unlike wild-type cells

• however, treatment with exogenous IL2 increased proliferation response and proliferation in response to concanavalin A is normal

enlarged thymus ( J:205441 )

• slightly

decreased regulatory T cell number ( J:205441 )

• in the thymus and spleen

decreased interferon-gamma secretion ( J:205441 )

• production from T cell fails to respond in a synergistic way to anti-CD3 and anti-CD28 antibodies unlike wild-type cells

decreased interleukin-2 secretion ( J:205441 )

• production from T cell fails to respond in a synergistic way to anti-CD3 and anti-CD28 antibodies unlike wild-type cells

hematopoietic system

decreased T cell proliferation ( J:205441 )

• T cell proliferation fails to respond in a synergistic way to anti-CD3 and anti-CD28 antibodies unlike wild-type cells

• however, treatment with exogenous IL2 increased proliferation response and proliferation in response to concanavalin A is normal

enlarged thymus ( J:205441 )

• slightly

decreased regulatory T cell number ( J:205441 )

• in the thymus and spleen

endocrine/exocrine glands

enlarged thymus ( J:205441 )

• slightly

cellular

decreased T cell proliferation ( J:205441 )

• T cell proliferation fails to respond in a synergistic way to anti-CD3 and anti-CD28 antibodies unlike wild-type cells

• however, treatment with exogenous IL2 increased proliferation response and proliferation in response to concanavalin A is normal

Allelic Composition	Carmil2^bas/Carmil2^{tm1a(KOMP)Mbp}
Genetic Background	involves: C3HeB/FeJ * C57BL/6 * C57BL/6N
Cell Lines	DEPD00524_2_G07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Carmil2^bas mutation (0 available); any Carmil2 mutation (39 available)
Carmil2^{tm1a(KOMP)Mbp} mutation (1 available); any Carmil2 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:205441 )

• T cell proliferation fails to respond in a synergistic way to anti-CD3 and anti-CD28 antibodies unlike wild-type cells

decreased regulatory T cell number ( J:205441 )

• in the thymus and spleen as in Rltpr^Bas homozygotes

decreased interleukin-2 secretion ( J:205441 )

• production from T cell fails to respond in a synergistic way to anti-CD3 and anti-CD28 antibodies unlike wild-type cells

hematopoietic system

decreased T cell proliferation ( J:205441 )

• T cell proliferation fails to respond in a synergistic way to anti-CD3 and anti-CD28 antibodies unlike wild-type cells

decreased regulatory T cell number ( J:205441 )

• in the thymus and spleen as in Rltpr^Bas homozygotes

cellular

decreased T cell proliferation ( J:205441 )

• T cell proliferation fails to respond in a synergistic way to anti-CD3 and anti-CD28 antibodies unlike wild-type cells

Allelic Composition	Lat^tm9Mal/Lat^tm9Mal Carmil2^bas/Carmil2^bas
Genetic Background	involves: C3HeB/FeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Carmil2^bas mutation (0 available); any Carmil2 mutation (39 available)
Lat^tm9Mal mutation (0 available); any Lat mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:205441 )

N	• unlike Lat^tm8Mal homozygotes, mice exhibit normal numbers of CD4+ T cells and Th2 effector cells

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