Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nedd4ltm1Shkr targeted mutation 1, Sharad Kumar MGI:5546607 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• Background Sensitivity: mice on a mixed background with 129 exhibit rescue of perinatal lethality observed in mice on a background without 129
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• mice survive up to P25 before dying of lung inflammation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice that survive beyond birth die by P22
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• few mice survive beyond birth
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| N |
• mice exhibit normal surfactant and mucous
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• with increased neutrophils as early as P14 in mice that survive to P22
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• necrosis of alveolar epithelium in mice that survive to P22
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• collapsed alveolar space at E18.5
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• in most mice delivered by caesarian section
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• in the lungs of mice that survive to P22
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• with increased neutrophils as early as P14 in mice that survive to P22
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• in the lungs of mice that survive to P22
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• when fed a normal, but not high, salt diet
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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