Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nedd4ltm1Shkr mutation
(0 available);
any
Nedd4l mutation
(71 available)
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mortality/aging
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N |
• Background Sensitivity: mice on a mixed background with 129 exhibit rescue of perinatal lethality observed in mice on a background without 129
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• mice survive up to P25 before dying of lung inflammation
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respiratory system
immune system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nedd4ltm1Shkr mutation
(0 available);
any
Nedd4l mutation
(71 available)
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mortality/aging
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• few mice survive beyond birth
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• mice that survive beyond birth die by P22
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respiratory system
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N |
• mice exhibit normal surfactant and mucous
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• necrosis of alveolar epithelium in mice that survive to P22
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• with increased neutrophils as early as P14 in mice that survive to P22
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• collapsed alveolar space at E18.5
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• in most mice delivered by caesarian section
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homeostasis/metabolism
immune system
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• in the lungs of mice that survive to P22
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• with increased neutrophils as early as P14 in mice that survive to P22
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hematopoietic system
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• in the lungs of mice that survive to P22
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cellular
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• necrosis of alveolar epithelium in mice that survive to P22
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Allelic
Composition |
Nedd4ltm1Shkr/Nedd4l+
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Genetic
Background |
involves: C57BL/6 * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nedd4ltm1Shkr mutation
(0 available);
any
Nedd4l mutation
(71 available)
|
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cardiovascular system
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• when fed a normal, but not high, salt diet
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Analysis Tools